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Breast cancer is one of the most prevalent tumor types, largely affecting women, but also a small number of men. Although the disease is relatively well understood in comparison to other tumor types, significant unmet needs exist.

Our multi functional nanobindi based products  use core shell architecture to deliver the chemotherapy. It does not contain chemical solvents, like Cremophor. This eliminates the need for premedication with steroids or antihistamines for hypersensitivity reactions caused by these solvents. Plus, since our products can be administered in just 5 minutes or less (compared to 3 hours for solvent-based paclitaxel), it is very patient friendly.

 

 

How our products Work

Paclitaxel and docetaxel are the active agents in PTXL-423 and DTXL-511. They are potent anticancer drug that stops cancer cells from growing and dividing by interfering with certain cell structures and killing the cancer cells. Both these compounds can slow tumor growth or temporarily stop tumor growth altogether.

Solvent-based drug contains chemicals that are needed to dissolve the drug before it can be injected into the bloodstream. These solvents can cause side effects; therefore, patients usually need to take additional medications before they receive solvent-based paclitaxel to reduce the risk of getting these solvent-related side effects.

PTXL-423 offers a different approach for treating metastatic breast cancer with paclitaxel by using our multifunctional target specific nanobindis to deliver the paclitaxel.

Because PTXL-423 is delivered at the site in its most efficacious state and does not contain solvents, there is a reduced risk of certain hypersensitivity-related side effects, so additional medications, such as steroids and antihistamines, are not necessary.


Products

PTXL-423: Paclitaxel containing TSDV for breast cancer

DTXL-511: Docetaxel containing TSDV for breast cancer

Company plans to conduct bioequivalence studies for both the products by early 2009 for following treatments.

1. Locally Advanced or Metastatic Breast Cancer

2. Adjuvant Treatment in Operable, Node-Positive Breast Cancer

 

 
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©2008 Chikujee Therapeutics, Inc. All rights reserved.